Rybelsus should always be taken once daily (1 tablet per day). Patients should be switched directly to the new equivalent strength:
If dose escalation due, patients can be switched to the higher new strength. Patients should be informed about the change in formulation and strength when prescribing or dispensing and new patients should start on the new formulation only. Old and new formulations will co-exist temporarily, risking confusion or duplication → may cause overdosing. The old formulation will be discontinued once most patients have been switched.
